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Those with sixth nerve palsy therefore experience horizontal double vision which is worse when looking towards the affected side.

More rarely, the oculomotor nerve and trochlear nerve (third and fourth nerve palsy, respectively) are affected; both play a role in eye movements.

Both biopsy samples and various types of brain scans have shown an increased water content of the brain tissue. It is not clear whether this narrowing is the pathogenesis of the disease or a secondary phenomenon.

It has been proposed that a positive biofeedback loop may exist, where raised ICP (intracranial pressure) causes venous narrowing in the transverse sinuses, resulting in venous hypertension (raised venous pressure), decreased CSF resorption via arachnoid granulation and further rise in ICP.

Longstanding papilledema leads to optic atrophy, in which the disc looks pale and visual loss tends to be advanced. Therefore, IIH can only be diagnosed if there is no alternative explanation for the symptoms.

The first theory, that of increased production of cerebrospinal fluid, was proposed in early descriptions of the disease.

Occasionally, the CSF pressure measurement may be normal despite very suggestive symptoms.

This may be attributable to the fact that CSF pressure may fluctuate over the course of the normal day.

isotretinoin for acne), long-term tetracycline antibiotics (for a variety of skin conditions) and hormonal contraceptives.

There are numerous other diseases, mostly rare conditions, that may lead to intracranial hypertension.